The human and canine TERT promoters function equivalently in human and canine cells

Research output: Contribution to journalJournal articleResearchpeer-review

Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics.

Original languageEnglish
JournalVeterinary and Comparative Oncology
Issue number4
Pages (from-to)310-6
Number of pages7
Publication statusPublished - Dec 2010

Bibliographical note

© 2010 Blackwell Publishing Ltd.

    Research areas

  • Animals, Cell Line, Dogs, Gene Expression Regulation/physiology, Humans, Plasmids, Promoter Regions, Genetic/genetics, Telomerase/genetics

ID: 209173199