Investigations on the potential role of prostaglandin E2 in canine uterine inertia

Research output: Contribution to journal › Journal article › Research › peer-review

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Investigations on the potential role of prostaglandin E2 in canine uterine inertia. / Rempel, Lea Magdalena; Körber, Hanna; Reichler, Iris M.; Balogh, Orsolya; Goericke-Pesch, Sandra.

In: Theriogenology, Vol. 175, 2021, p. 134-147.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rempel, LM, Körber, H, Reichler, IM, Balogh, O & Goericke-Pesch, S 2021, 'Investigations on the potential role of prostaglandin E2 in canine uterine inertia', Theriogenology, vol. 175, pp. 134-147. https://doi.org/10.1016/j.theriogenology.2021.09.003

APA

Rempel, L. M., Körber, H., Reichler, I. M., Balogh, O., & Goericke-Pesch, S. (2021). Investigations on the potential role of prostaglandin E2 in canine uterine inertia. Theriogenology, 175, 134-147. https://doi.org/10.1016/j.theriogenology.2021.09.003

Vancouver

Rempel LM, Körber H, Reichler IM, Balogh O, Goericke-Pesch S. Investigations on the potential role of prostaglandin E2 in canine uterine inertia. Theriogenology. 2021;175:134-147. https://doi.org/10.1016/j.theriogenology.2021.09.003

Author

Rempel, Lea Magdalena ; Körber, Hanna ; Reichler, Iris M. ; Balogh, Orsolya ; Goericke-Pesch, Sandra. / Investigations on the potential role of prostaglandin E2 in canine uterine inertia. In: Theriogenology. 2021 ; Vol. 175. pp. 134-147.

Bibtex

@article{a64ba7bd841c43d29c82c3704dbe0a95,
title = "Investigations on the potential role of prostaglandin E2 in canine uterine inertia",
abstract = "Prostaglandin (PG) E2 plays a crucial role in the endocrine network of canine parturition and we hypothesized that PGE2, 15-hydroxyprostaglandin dehydrogenase (HPGD) and PG-transporter (PGT) might be involved in the development of primary uterine inertia (PUI). We investigated PTGE synthase (PTGES), PTGE receptors 2/4 (PTGER2/4), HPGD and PGT expression on the mRNA- and protein-level in interplacental (IP) and uteroplacental (UP) tissues of bitches presented with dystocia undergoing emergency caesarean section. Groups were formed retrospectively based on strict criteria: PUI (n = 12; small/normal/large litter - PUI-S/N/L: n = 5/4/3), and obstructive dystocia (OD, n = 8). Respective mRNA expressions (ratio) between PUI and OD in IP and UP, between PUI dogs with different litter sizes, between PUI-N and OD in IP, and overall between IP and UP were compared. PTGES, PTGER2, PTGER4, HPGD and PGT mRNA expressions did not differ significantly between PUI and OD in IP or UP. PUI-N PTGES mRNA expression was higher than PUI-S/L (P = 0.0203/P = 0.0186) and OD (P = 0.0314). Higher PTGES (P = 0.0112) and a tendency for higher PTGER2 (P = 0.059) mRNA-expressions were detected in UP versus IP. Other than hypothesized, we did not find a difference in PGE2 production and signaling between PUI and OD, indicating that altered uterine PTGES, PTGER2, PTGER4, HPGD and PGT expression was likely not causative for PUI. However, higher PTGES expression in PUI-N compared to OD might point to a possible role of PGE2 during the course of parturition. Higher PTGES expression in PUI-N compared to PUI-S/L indicates an influence of litter size, the underlying cause and biological relevance of which remain to be clarified.",
keywords = "Dog, Dystocia, Parturition, Placenta, Prostaglandin, Uterine inertia, Uterus",
author = "Rempel, {Lea Magdalena} and Hanna K{\"o}rber and Reichler, {Iris M.} and Orsolya Balogh and Sandra Goericke-Pesch",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
doi = "10.1016/j.theriogenology.2021.09.003",
language = "English",
volume = "175",
pages = "134--147",
journal = "Theriogenology",
issn = "0093-691X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Investigations on the potential role of prostaglandin E2 in canine uterine inertia

AU - Rempel, Lea Magdalena

AU - Körber, Hanna

AU - Reichler, Iris M.

AU - Balogh, Orsolya

AU - Goericke-Pesch, Sandra

N1 - Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021

Y1 - 2021

N2 - Prostaglandin (PG) E2 plays a crucial role in the endocrine network of canine parturition and we hypothesized that PGE2, 15-hydroxyprostaglandin dehydrogenase (HPGD) and PG-transporter (PGT) might be involved in the development of primary uterine inertia (PUI). We investigated PTGE synthase (PTGES), PTGE receptors 2/4 (PTGER2/4), HPGD and PGT expression on the mRNA- and protein-level in interplacental (IP) and uteroplacental (UP) tissues of bitches presented with dystocia undergoing emergency caesarean section. Groups were formed retrospectively based on strict criteria: PUI (n = 12; small/normal/large litter - PUI-S/N/L: n = 5/4/3), and obstructive dystocia (OD, n = 8). Respective mRNA expressions (ratio) between PUI and OD in IP and UP, between PUI dogs with different litter sizes, between PUI-N and OD in IP, and overall between IP and UP were compared. PTGES, PTGER2, PTGER4, HPGD and PGT mRNA expressions did not differ significantly between PUI and OD in IP or UP. PUI-N PTGES mRNA expression was higher than PUI-S/L (P = 0.0203/P = 0.0186) and OD (P = 0.0314). Higher PTGES (P = 0.0112) and a tendency for higher PTGER2 (P = 0.059) mRNA-expressions were detected in UP versus IP. Other than hypothesized, we did not find a difference in PGE2 production and signaling between PUI and OD, indicating that altered uterine PTGES, PTGER2, PTGER4, HPGD and PGT expression was likely not causative for PUI. However, higher PTGES expression in PUI-N compared to OD might point to a possible role of PGE2 during the course of parturition. Higher PTGES expression in PUI-N compared to PUI-S/L indicates an influence of litter size, the underlying cause and biological relevance of which remain to be clarified.

AB - Prostaglandin (PG) E2 plays a crucial role in the endocrine network of canine parturition and we hypothesized that PGE2, 15-hydroxyprostaglandin dehydrogenase (HPGD) and PG-transporter (PGT) might be involved in the development of primary uterine inertia (PUI). We investigated PTGE synthase (PTGES), PTGE receptors 2/4 (PTGER2/4), HPGD and PGT expression on the mRNA- and protein-level in interplacental (IP) and uteroplacental (UP) tissues of bitches presented with dystocia undergoing emergency caesarean section. Groups were formed retrospectively based on strict criteria: PUI (n = 12; small/normal/large litter - PUI-S/N/L: n = 5/4/3), and obstructive dystocia (OD, n = 8). Respective mRNA expressions (ratio) between PUI and OD in IP and UP, between PUI dogs with different litter sizes, between PUI-N and OD in IP, and overall between IP and UP were compared. PTGES, PTGER2, PTGER4, HPGD and PGT mRNA expressions did not differ significantly between PUI and OD in IP or UP. PUI-N PTGES mRNA expression was higher than PUI-S/L (P = 0.0203/P = 0.0186) and OD (P = 0.0314). Higher PTGES (P = 0.0112) and a tendency for higher PTGER2 (P = 0.059) mRNA-expressions were detected in UP versus IP. Other than hypothesized, we did not find a difference in PGE2 production and signaling between PUI and OD, indicating that altered uterine PTGES, PTGER2, PTGER4, HPGD and PGT expression was likely not causative for PUI. However, higher PTGES expression in PUI-N compared to OD might point to a possible role of PGE2 during the course of parturition. Higher PTGES expression in PUI-N compared to PUI-S/L indicates an influence of litter size, the underlying cause and biological relevance of which remain to be clarified.

KW - Dog

KW - Dystocia

KW - Parturition

KW - Placenta

KW - Prostaglandin

KW - Uterine inertia

KW - Uterus

U2 - 10.1016/j.theriogenology.2021.09.003

DO - 10.1016/j.theriogenology.2021.09.003

M3 - Journal article

C2 - 34544012

AN - SCOPUS:85115020413

VL - 175

SP - 134

EP - 147

JO - Theriogenology

JF - Theriogenology

SN - 0093-691X

ER -

ID: 280736612