Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs
Research output: Contribution to journal › Journal article › Research › peer-review
The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.
Original language | English |
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Journal | Canadian Veterinary Journal |
Volume | 55 |
Issue number | 2 |
Pages (from-to) | 161-168 |
Number of pages | 8 |
ISSN | 0008-5286 |
Publication status | Published - 2014 |
ID: 99928634