The human and canine TERT promoters function equivalently in human and canine cells
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The human and canine TERT promoters function equivalently in human and canine cells. / Arendt, M L; Nasir, L; Morgan, I M.
I: Veterinary and Comparative Oncology, Bind 8, Nr. 4, 12.2010, s. 310-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The human and canine TERT promoters function equivalently in human and canine cells
AU - Arendt, M L
AU - Nasir, L
AU - Morgan, I M
N1 - © 2010 Blackwell Publishing Ltd.
PY - 2010/12
Y1 - 2010/12
N2 - Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics.
AB - Telomerase targeted cancer gene therapy is being exploited for treatment of human cancer. The high incidence and many comparative aspects of human and canine cancer and the compliance and dedication of dog owners to treat cancer makes the canine pet population a good clinical model for investigating and developing new cancer therapeutics. Here, we report that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. Therefore, the canine pet population can act as a clinical model for new drug development based on telomerase therapeutics.
KW - Animals
KW - Cell Line
KW - Dogs
KW - Gene Expression Regulation/physiology
KW - Humans
KW - Plasmids
KW - Promoter Regions, Genetic/genetics
KW - Telomerase/genetics
U2 - 10.1111/j.1476-5829.2010.00227.x
DO - 10.1111/j.1476-5829.2010.00227.x
M3 - Journal article
C2 - 21062413
VL - 8
SP - 310
EP - 316
JO - Veterinary and Comparative Oncology
JF - Veterinary and Comparative Oncology
SN - 1476-5810
IS - 4
ER -
ID: 209173199