The genomic signature of dog domestication reveals adaptation to a starch-rich diet
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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The genomic signature of dog domestication reveals adaptation to a starch-rich diet. / Axelsson, Erik; Ratnakumar, Abhirami; Arendt, Maja-Louise; Maqbool, Khurram; Webster, Matthew T.; Perloski, Michele; Liberg, Olof; Arnemo, Jon M; Hedhammar, Ake; Lindblad-Toh, Kerstin.
I: Nature, Bind 495, Nr. 7441, 2013, s. 360-364.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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T1 - The genomic signature of dog domestication reveals adaptation to a starch-rich diet
AU - Axelsson, Erik
AU - Ratnakumar, Abhirami
AU - Arendt, Maja-Louise
AU - Maqbool, Khurram
AU - Webster, Matthew T.
AU - Perloski, Michele
AU - Liberg, Olof
AU - Arnemo, Jon M
AU - Hedhammar, Ake
AU - Lindblad-Toh, Kerstin
PY - 2013
Y1 - 2013
N2 - The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs and wolves to identify 3.8 million genetic variants used to identify 36 genomic regions that probably represent targets for selection during dog domestication. Nineteen of these regions contain genes important in brain function, eight of which belong to nervous system development pathways and potentially underlie behavioural changes central to dog domestication. Ten genes with key roles in starch digestion and fat metabolism also show signals of selection. We identify candidate mutations in key genes and provide functional support for an increased starch digestion in dogs relative to wolves. Our results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication of dogs.
AB - The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs and wolves to identify 3.8 million genetic variants used to identify 36 genomic regions that probably represent targets for selection during dog domestication. Nineteen of these regions contain genes important in brain function, eight of which belong to nervous system development pathways and potentially underlie behavioural changes central to dog domestication. Ten genes with key roles in starch digestion and fat metabolism also show signals of selection. We identify candidate mutations in key genes and provide functional support for an increased starch digestion in dogs relative to wolves. Our results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication of dogs.
KW - Amylases/genetics
KW - Animals
KW - Animals, Domestic/genetics
KW - Diet/veterinary
KW - Dogs/genetics
KW - Genome/genetics
KW - Glycogen Storage Disease Type II
KW - Mutation
KW - Starch
KW - Wolves/genetics
KW - alpha-Glucosidases/genetics
U2 - 10.1038/nature11837
DO - 10.1038/nature11837
M3 - Letter
C2 - 23354050
VL - 495
SP - 360
EP - 364
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7441
ER -
ID: 209172990