Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke

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Standard

Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke. / Thomsen, Barbara Blicher; Gredal, Hanne; Wirenfeldt, Martin; Kristensen, Bjarne Winther; Clausen, Bettina Hjelm; Larsen, Anders Elm; Finsen, Bente; Berendt, Mette; Lambertsen, Kate Lykke.

I: Acta Veterinaria Scandinavica, Bind 59, 7, 01.2017.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Thomsen, BB, Gredal, H, Wirenfeldt, M, Kristensen, BW, Clausen, BH, Larsen, AE, Finsen, B, Berendt, M & Lambertsen, KL 2017, 'Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke', Acta Veterinaria Scandinavica, bind 59, 7. https://doi.org/10.1186/s13028-016-0275-7

APA

Thomsen, B. B., Gredal, H., Wirenfeldt, M., Kristensen, B. W., Clausen, B. H., Larsen, A. E., Finsen, B., Berendt, M., & Lambertsen, K. L. (2017). Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke. Acta Veterinaria Scandinavica, 59, [7]. https://doi.org/10.1186/s13028-016-0275-7

Vancouver

Thomsen BB, Gredal H, Wirenfeldt M, Kristensen BW, Clausen BH, Larsen AE o.a. Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke. Acta Veterinaria Scandinavica. 2017 jan.;59. 7. https://doi.org/10.1186/s13028-016-0275-7

Author

Thomsen, Barbara Blicher ; Gredal, Hanne ; Wirenfeldt, Martin ; Kristensen, Bjarne Winther ; Clausen, Bettina Hjelm ; Larsen, Anders Elm ; Finsen, Bente ; Berendt, Mette ; Lambertsen, Kate Lykke. / Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke. I: Acta Veterinaria Scandinavica. 2017 ; Bind 59.

Bibtex

@article{8c25cdb23d0f4cecbc8ccf53ef39d2e2,
title = "Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke",
abstract = "BackgroundDogs develop spontaneous ischaemic stroke with a clinical picture closely resembling human ischaemic stroke patients. Animal stroke models have been developed, but it has proved difficult to translate results obtained from such models into successful therapeutic strategies in human stroke patients. In order to face this apparent translational gap within stroke research, dogs with ischaemic stroke constitute an opportunity to study the neuropathology of ischaemic stroke in an animal species.Case presentationA 7 years and 8 months old female neutered Rottweiler dog suffered a middle cerebral artery infarct and was euthanized 3 days after onset of neurological signs. The brain was subjected to histopathology and immunohistochemistry. Neuropathological changes were characterised by a pan-necrotic infarct surrounded by peri-infarct injured neurons and reactive microglia/macrophages and astrocytes.ConclusionsThe neuropathological changes reported in the present study were similar to findings in human patients with ischaemic stroke. The dog with spontaneous ischaemic stroke is of interest as a complementary spontaneous animal model for further neuropathological studies.",
keywords = "Animal model, Astrocyte, Canine, Cerebral infarction, Cerebrovascular accident, Infarct, Microglia, Middle cerebral artery occlusion",
author = "Thomsen, {Barbara Blicher} and Hanne Gredal and Martin Wirenfeldt and Kristensen, {Bjarne Winther} and Clausen, {Bettina Hjelm} and Larsen, {Anders Elm} and Bente Finsen and Mette Berendt and Lambertsen, {Kate Lykke}",
year = "2017",
month = jan,
doi = "10.1186/s13028-016-0275-7",
language = "English",
volume = "59",
journal = "Acta Veterinaria Scandinavica",
issn = "0044-605X",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke

AU - Thomsen, Barbara Blicher

AU - Gredal, Hanne

AU - Wirenfeldt, Martin

AU - Kristensen, Bjarne Winther

AU - Clausen, Bettina Hjelm

AU - Larsen, Anders Elm

AU - Finsen, Bente

AU - Berendt, Mette

AU - Lambertsen, Kate Lykke

PY - 2017/1

Y1 - 2017/1

N2 - BackgroundDogs develop spontaneous ischaemic stroke with a clinical picture closely resembling human ischaemic stroke patients. Animal stroke models have been developed, but it has proved difficult to translate results obtained from such models into successful therapeutic strategies in human stroke patients. In order to face this apparent translational gap within stroke research, dogs with ischaemic stroke constitute an opportunity to study the neuropathology of ischaemic stroke in an animal species.Case presentationA 7 years and 8 months old female neutered Rottweiler dog suffered a middle cerebral artery infarct and was euthanized 3 days after onset of neurological signs. The brain was subjected to histopathology and immunohistochemistry. Neuropathological changes were characterised by a pan-necrotic infarct surrounded by peri-infarct injured neurons and reactive microglia/macrophages and astrocytes.ConclusionsThe neuropathological changes reported in the present study were similar to findings in human patients with ischaemic stroke. The dog with spontaneous ischaemic stroke is of interest as a complementary spontaneous animal model for further neuropathological studies.

AB - BackgroundDogs develop spontaneous ischaemic stroke with a clinical picture closely resembling human ischaemic stroke patients. Animal stroke models have been developed, but it has proved difficult to translate results obtained from such models into successful therapeutic strategies in human stroke patients. In order to face this apparent translational gap within stroke research, dogs with ischaemic stroke constitute an opportunity to study the neuropathology of ischaemic stroke in an animal species.Case presentationA 7 years and 8 months old female neutered Rottweiler dog suffered a middle cerebral artery infarct and was euthanized 3 days after onset of neurological signs. The brain was subjected to histopathology and immunohistochemistry. Neuropathological changes were characterised by a pan-necrotic infarct surrounded by peri-infarct injured neurons and reactive microglia/macrophages and astrocytes.ConclusionsThe neuropathological changes reported in the present study were similar to findings in human patients with ischaemic stroke. The dog with spontaneous ischaemic stroke is of interest as a complementary spontaneous animal model for further neuropathological studies.

KW - Animal model

KW - Astrocyte

KW - Canine

KW - Cerebral infarction

KW - Cerebrovascular accident

KW - Infarct

KW - Microglia

KW - Middle cerebral artery occlusion

U2 - 10.1186/s13028-016-0275-7

DO - 10.1186/s13028-016-0275-7

M3 - Journal article

C2 - 28086932

VL - 59

JO - Acta Veterinaria Scandinavica

JF - Acta Veterinaria Scandinavica

SN - 0044-605X

M1 - 7

ER -

ID: 186319832