Serum amyloid A does not predict non-survival in hospitalised adult horses with acute colitis
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Serum amyloid A does not predict non-survival in hospitalised adult horses with acute colitis. / Runge, Kira Elisabeth; Bak, Maj; Vestergaard, Amalie; Stærk-Østergaard, Jacob; Jacobsen, Stine; Pihl, Tina Holberg.
I: Veterinary Record, Bind 192, Nr. 7, e2644, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Serum amyloid A does not predict non-survival in hospitalised adult horses with acute colitis
AU - Runge, Kira Elisabeth
AU - Bak, Maj
AU - Vestergaard, Amalie
AU - Stærk-Østergaard, Jacob
AU - Jacobsen, Stine
AU - Pihl, Tina Holberg
N1 - Publisher Copyright: © 2023 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.
PY - 2023
Y1 - 2023
N2 - Background: Predicting non-survival in horses with acute colitis improves early decision making. Therefore, this study aimed to determine the prognostic value of serum amyloid A (SAA) and other clinicopathological and clinical variables in adult horses with acute colitis. Methods: Clinical variables, SAA and other blood biomarkers, including plasma L-lactate (lactate), were assessed in 176 horses with acute colitis. A multivariate model for the prediction of non-survival was constructed. Icelandic horses were analysed separately. Results: Admission SAA was similar in survivors (median 548 mg/L; range 0–5453 mg/L) and non-survivors (396 mg/L; 0–5294) (p = 0.43). A model for non-survival included year of admission, lactate, heart rate, age and colic duration of more than 24 hours. Icelandic horses had a relative risk of 2.9 (95% confidence interval = 2.2–3.8) for acute colitis compared to other breeds. Lactate in Icelandic horses was higher than that in other breeds in both survivors (4.0 mmol/L, range 1.0–12.7 vs. 2.0, 0.7–12.5) and non-survivors (10.0, 1.5–26 vs. 5.4, 0.8–22) (p < 0.001). Limitations: The prognostic value of repeated measurements of SAA could not be assessed in this study, as 71% of the non-surviving horses died within a day of admission. Conclusion: Admission SAA did not predict non-survival. Breed needs consideration when lactate is evaluated as a predictor for non-survival in horses with colitis.
AB - Background: Predicting non-survival in horses with acute colitis improves early decision making. Therefore, this study aimed to determine the prognostic value of serum amyloid A (SAA) and other clinicopathological and clinical variables in adult horses with acute colitis. Methods: Clinical variables, SAA and other blood biomarkers, including plasma L-lactate (lactate), were assessed in 176 horses with acute colitis. A multivariate model for the prediction of non-survival was constructed. Icelandic horses were analysed separately. Results: Admission SAA was similar in survivors (median 548 mg/L; range 0–5453 mg/L) and non-survivors (396 mg/L; 0–5294) (p = 0.43). A model for non-survival included year of admission, lactate, heart rate, age and colic duration of more than 24 hours. Icelandic horses had a relative risk of 2.9 (95% confidence interval = 2.2–3.8) for acute colitis compared to other breeds. Lactate in Icelandic horses was higher than that in other breeds in both survivors (4.0 mmol/L, range 1.0–12.7 vs. 2.0, 0.7–12.5) and non-survivors (10.0, 1.5–26 vs. 5.4, 0.8–22) (p < 0.001). Limitations: The prognostic value of repeated measurements of SAA could not be assessed in this study, as 71% of the non-surviving horses died within a day of admission. Conclusion: Admission SAA did not predict non-survival. Breed needs consideration when lactate is evaluated as a predictor for non-survival in horses with colitis.
U2 - 10.1002/vetr.2644
DO - 10.1002/vetr.2644
M3 - Journal article
C2 - 36780213
AN - SCOPUS:85148014677
VL - 192
JO - Veterinary Record
JF - Veterinary Record
SN - 0042-4900
IS - 7
M1 - e2644
ER -
ID: 337599173