Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals
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Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals. / Hoeberg, Emma; Sånge, Alexandra; Saegerman, Claude; Bohlin, Anna; Nostell, Katarina; Durie, Inge; Husted, Louise; Öhman, Anna; Jacobsen, Stine; Berg, Lise; Laursen, Sigrid Hyldahl; van Galen, Gaby.
I: Journal of Veterinary Internal Medicine, Bind 36, Nr. 6, 2022, s. 2245-2253.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals
AU - Hoeberg, Emma
AU - Sånge, Alexandra
AU - Saegerman, Claude
AU - Bohlin, Anna
AU - Nostell, Katarina
AU - Durie, Inge
AU - Husted, Louise
AU - Öhman, Anna
AU - Jacobsen, Stine
AU - Berg, Lise
AU - Laursen, Sigrid Hyldahl
AU - van Galen, Gaby
N1 - Publisher Copyright: © 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
PY - 2022
Y1 - 2022
N2 - Background: Serum amyloid A (SAA) has been reported to hold promise as diagnostic and prognostic marker in foals. This has not been investigated thoroughly. Objectives: Evaluate admission SAA concentrations as predictor of sepsis and outcome. Animals: Five hundred and ninety hospitalized foals <14 days old. Methods: Retrospective multicenter study. Foals were scored with sepsis and survival scores, grouped according to health category (septic, sick but nonseptic, uncertain sepsis status) and outcome; septic foals were further categorized according to severity (normal sepsis, severe sepsis, and septic shock). SAA was compared between groups using Mann-Whitney test and Kruskal-Wallis test. Receiver operating characteristic curves identified optimal SAA cut off values for detecting sepsis and predicting outcome. Results: Admission SAA concentrations differed significantly between sick nonseptic foals (312.1 ± 685.4 mg/L) and septic foals (1079.7 ± 1254.5 mg/L) and increased with increasing sepsis score. SAA did not differ between sepsis severity groups. The optimal cut off for sepsis detection was 1050 mg/L (sensitivity 30.2%, specificity 90.7%). Admission SAA concentrations were lower in surviving (435.0 ± 723.6 mg/L) compared to nonsurviving foals (1062.7 ± 1440.1 mg/L) and decreased with increasing survival score. The optimal cut off for nonsurvival prediction was 1250 mg/L (sensitivity 22.1%, specificity 90.8%). Conclusions and Clinical Importance: SAA concentration was higher in septic foals and nonsurviving foals. Even though optimal cut offs for SAA to detect sepsis and predict outcome had low sensitivity, they had good specificity. SAA can therefore be used as a marker to rule out sepsis and nonsurvival.
AB - Background: Serum amyloid A (SAA) has been reported to hold promise as diagnostic and prognostic marker in foals. This has not been investigated thoroughly. Objectives: Evaluate admission SAA concentrations as predictor of sepsis and outcome. Animals: Five hundred and ninety hospitalized foals <14 days old. Methods: Retrospective multicenter study. Foals were scored with sepsis and survival scores, grouped according to health category (septic, sick but nonseptic, uncertain sepsis status) and outcome; septic foals were further categorized according to severity (normal sepsis, severe sepsis, and septic shock). SAA was compared between groups using Mann-Whitney test and Kruskal-Wallis test. Receiver operating characteristic curves identified optimal SAA cut off values for detecting sepsis and predicting outcome. Results: Admission SAA concentrations differed significantly between sick nonseptic foals (312.1 ± 685.4 mg/L) and septic foals (1079.7 ± 1254.5 mg/L) and increased with increasing sepsis score. SAA did not differ between sepsis severity groups. The optimal cut off for sepsis detection was 1050 mg/L (sensitivity 30.2%, specificity 90.7%). Admission SAA concentrations were lower in surviving (435.0 ± 723.6 mg/L) compared to nonsurviving foals (1062.7 ± 1440.1 mg/L) and decreased with increasing survival score. The optimal cut off for nonsurvival prediction was 1250 mg/L (sensitivity 22.1%, specificity 90.8%). Conclusions and Clinical Importance: SAA concentration was higher in septic foals and nonsurviving foals. Even though optimal cut offs for SAA to detect sepsis and predict outcome had low sensitivity, they had good specificity. SAA can therefore be used as a marker to rule out sepsis and nonsurvival.
KW - biomarker
KW - equine
KW - prognosis
U2 - 10.1111/jvim.16550
DO - 10.1111/jvim.16550
M3 - Journal article
C2 - 36239317
AN - SCOPUS:85139876379
VL - 36
SP - 2245
EP - 2253
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 6
ER -
ID: 323848281