Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye
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Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye. / Meydan, Hassan; Dibiç, Kübra Bedir ; Vural, Onur ; Yildiz, Mehmet Ali; Agerholm, Jørgen Steen.
I: Turkish Journal of Veterinary and Animal Sciences, Bind 47, Nr. 6, 9, 2023, s. 584-587.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Prevalence of carriers of cholesterol deficiency–associated APOB mutation in some native, Holstein and Simmental cattle breeds in Türkiye
AU - Meydan, Hassan
AU - Dibiç, Kübra Bedir
AU - Vural, Onur
AU - Yildiz, Mehmet Ali
AU - Agerholm, Jørgen Steen
PY - 2023
Y1 - 2023
N2 - Genetic diseases play an increasingly important role in cattle breeding as breeding technologies such as artificial insemination has an inborn risk of disseminating deleterious genes, especially from high merit breeding sires. Cholesterol deficiency (CD) is a metabolic disorder first recognized in Holstein cattle in 2015. The condition is characterized by chronic diarrhea and unthriftiness in calves being homozygous for the defective allele. The prevalence of carriers of CD in Turkish cattle is at present unknown and therefore 700 heifers and cows of different breeds, including 300 Holsteins were genotyped. Of the tested Holsteins, 2.0% turned out to be carriers of CD thus showing that the defective allele for CD is actually present in Turkish Holstein cattle. The carrier prevalence was between 0% and 4.0% in 4 different Holstein herds. Carriers were not found in other breeds tested, which included native Turkish cattle breeds. To avoid the birth of Holstein calves that will develop clinical signs of CD, sires should be tested for CD, and only homozygous normal individuals should be used for breeding.
AB - Genetic diseases play an increasingly important role in cattle breeding as breeding technologies such as artificial insemination has an inborn risk of disseminating deleterious genes, especially from high merit breeding sires. Cholesterol deficiency (CD) is a metabolic disorder first recognized in Holstein cattle in 2015. The condition is characterized by chronic diarrhea and unthriftiness in calves being homozygous for the defective allele. The prevalence of carriers of CD in Turkish cattle is at present unknown and therefore 700 heifers and cows of different breeds, including 300 Holsteins were genotyped. Of the tested Holsteins, 2.0% turned out to be carriers of CD thus showing that the defective allele for CD is actually present in Turkish Holstein cattle. The carrier prevalence was between 0% and 4.0% in 4 different Holstein herds. Carriers were not found in other breeds tested, which included native Turkish cattle breeds. To avoid the birth of Holstein calves that will develop clinical signs of CD, sires should be tested for CD, and only homozygous normal individuals should be used for breeding.
U2 - 10.55730/1300-0128.4328
DO - 10.55730/1300-0128.4328
M3 - Journal article
VL - 47
SP - 584
EP - 587
JO - Turkish Journal of Veterinary and Animal Sciences
JF - Turkish Journal of Veterinary and Animal Sciences
SN - 1300-0128
IS - 6
M1 - 9
ER -
ID: 380207904