Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life
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Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life. / Nielsen, Mette Olaf; Kongsted, Anna Hauntoft; Thygesen, M.P.; Strathe, Anders Bjerring; Caddy, S.; Quistorff, Bjørn; Jørgensen, Wenche; Christensen, Vibeke Grøsfjeld; Husted, Sanne Vinter; Chwalibog, André; Sejrsen, Kristen; Purup, Stig; Svalastoga, Eiliv Lars; McEvoy, Fintan; Johnsen, Lærke.
I: British Journal of Nutrition, Bind 109, Nr. 11, 2013, s. 2098-2110.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life
AU - Nielsen, Mette Olaf
AU - Kongsted, Anna Hauntoft
AU - Thygesen, M.P.
AU - Strathe, Anders Bjerring
AU - Caddy, S.
AU - Quistorff, Bjørn
AU - Jørgensen, Wenche
AU - Christensen, Vibeke Grøsfjeld
AU - Husted, Sanne Vinter
AU - Chwalibog, André
AU - Sejrsen, Kristen
AU - Purup, Stig
AU - Svalastoga, Eiliv Lars
AU - McEvoy, Fintan
AU - Johnsen, Lærke
PY - 2013
Y1 - 2013
N2 - We have developed a sheep model to facilitate studies of the fetal programming effects of mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty-one twin-bearing ewes were fed a normal diet fulfilling norms for energy and protein (NORM) or 50% of a normal diet (LOW). From day 3 postpartum to 6 months (around puberty) of age, one twin lamb was fed a conventional (CONV) diet and the other a high-carbohydrate-high-fat (HCHF) diet, resulting in four groups of offspring: NORM-CONV; NORMHCHF; LOW-CONV; LOW-HCHF. At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females only) were transferred to a moderate sheep diet until slaughtered at 24 months of age (adulthood). Maternal undernutrition during late gestation reduced the birth weight of LOW offspring (P
AB - We have developed a sheep model to facilitate studies of the fetal programming effects of mismatched perinatal and postnatal nutrition. During the last trimester of gestation, twenty-one twin-bearing ewes were fed a normal diet fulfilling norms for energy and protein (NORM) or 50% of a normal diet (LOW). From day 3 postpartum to 6 months (around puberty) of age, one twin lamb was fed a conventional (CONV) diet and the other a high-carbohydrate-high-fat (HCHF) diet, resulting in four groups of offspring: NORM-CONV; NORMHCHF; LOW-CONV; LOW-HCHF. At 6 months of age, half of the lambs (all males and three females) were slaughtered for further examination and the other half (females only) were transferred to a moderate sheep diet until slaughtered at 24 months of age (adulthood). Maternal undernutrition during late gestation reduced the birth weight of LOW offspring (P
U2 - 10.1017/S0007114512004199
DO - 10.1017/S0007114512004199
M3 - Journal article
C2 - 23069212
VL - 109
SP - 2098
EP - 2110
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 11
ER -
ID: 46456106