TY - JOUR

T1 - Effect of exercise on serum neutrophil gelatinase-associated lipocalin concentration in racehorses

AU - Flick, Marnie

AU - Vinther, Anne M.L.

AU - Jacobsen, Stine

AU - Berg, Lise C.

AU - Gimeno, Marina

AU - Verwilghen, Denis

AU - Howden, Wade

AU - Averay, Kate

AU - van Galen, Gaby

N1 - Funding Information: We owe thanks to Kathy Brammall for her help in conducting the creatinine analysis. Also, the trainer of the racehorses, Richard Litt, is gratefully acknowledged for allowing us to sample his horses. Publisher Copyright: © 2021 American Society for Veterinary Clinical Pathology

PY - 2021

Y1 - 2021

N2 - Serum neutrophil gelatinase-associated lipocalin (sNGAL) is a marker of renal injury, and its concentrations are affected by inflammation. Therefore, it could serve as a useful biomarker of disease or fitness in high-level competition. However, it has not yet been determined if sNGAL concentrations are affected by exercise. The aim of this study was to determine whether concentrations of equine sNGAL were affected by 1000 m galloping as the form of exercise used in the study. Pre- and post-gallop sNGAL, serum amyloid A, and creatinine concentrations were evaluated in 14 healthy Thoroughbred racehorses. The results showed that short, high-intensity exercise did not significantly affect sNGAL concentrations in healthy horses (P =.42), and no significant difference was found in either creatinine or serum amyloid A before and after galloping (P >.05). Therefore, it was determined that sNGAL was not influenced by the type of exercise used in the study and could have the potential to be used as a routine laboratory screening tool in horses even after strenuous exercise. Future research should clarify its use in a larger population and a broader range of equine sport disciplines, including endurance-related exercise.

AB - Serum neutrophil gelatinase-associated lipocalin (sNGAL) is a marker of renal injury, and its concentrations are affected by inflammation. Therefore, it could serve as a useful biomarker of disease or fitness in high-level competition. However, it has not yet been determined if sNGAL concentrations are affected by exercise. The aim of this study was to determine whether concentrations of equine sNGAL were affected by 1000 m galloping as the form of exercise used in the study. Pre- and post-gallop sNGAL, serum amyloid A, and creatinine concentrations were evaluated in 14 healthy Thoroughbred racehorses. The results showed that short, high-intensity exercise did not significantly affect sNGAL concentrations in healthy horses (P =.42), and no significant difference was found in either creatinine or serum amyloid A before and after galloping (P >.05). Therefore, it was determined that sNGAL was not influenced by the type of exercise used in the study and could have the potential to be used as a routine laboratory screening tool in horses even after strenuous exercise. Future research should clarify its use in a larger population and a broader range of equine sport disciplines, including endurance-related exercise.

U2 - 10.1111/vcp.13027

DO - 10.1111/vcp.13027

M3 - Journal article

C2 - 34779025

AN - SCOPUS:85119247636

VL - 50

SP - 551

EP - 554

JO - Veterinary Clinical Pathology

JF - Veterinary Clinical Pathology

SN - 0275-6382

IS - 4

ER -