Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. / Cremer, Signe Emilie; Moesgaard, S. G.; Rasmussen, C. E.; Zois, N. E.; Falk, T.; Reimann, Maria Josefine; Cirera Salicio, Susanna; Aupperle, H.; Oyama, M. A.; Olsen, Lisbeth Høier.

I: Research in Veterinary Science, Bind 100, 19.03.2015, s. 197-206.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Cremer, SE, Moesgaard, SG, Rasmussen, CE, Zois, NE, Falk, T, Reimann, MJ, Cirera Salicio, S, Aupperle, H, Oyama, MA & Olsen, LH 2015, 'Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease', Research in Veterinary Science, bind 100, s. 197-206. https://doi.org/10.1016/j.rvsc.2015.03.020

APA

Cremer, S. E., Moesgaard, S. G., Rasmussen, C. E., Zois, N. E., Falk, T., Reimann, M. J., Cirera Salicio, S., Aupperle, H., Oyama, M. A., & Olsen, L. H. (2015). Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. Research in Veterinary Science, 100, 197-206. https://doi.org/10.1016/j.rvsc.2015.03.020

Vancouver

Cremer SE, Moesgaard SG, Rasmussen CE, Zois NE, Falk T, Reimann MJ o.a. Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. Research in Veterinary Science. 2015 mar. 19;100:197-206. https://doi.org/10.1016/j.rvsc.2015.03.020

Author

Cremer, Signe Emilie ; Moesgaard, S. G. ; Rasmussen, C. E. ; Zois, N. E. ; Falk, T. ; Reimann, Maria Josefine ; Cirera Salicio, Susanna ; Aupperle, H. ; Oyama, M. A. ; Olsen, Lisbeth Høier. / Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. I: Research in Veterinary Science. 2015 ; Bind 100. s. 197-206.

Bibtex

@article{3abc53f97a674349804219ada2ce31af,
title = "Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease",
abstract = "Canine Myxomatous mitral valve disease (MMVD) is an age-related disease. Serotonin (5-HT) is implicated in the pathogenesis as locally-produced or platelet-derived. Involvement of the 5-HT2A receptor (R) and 5-HT2BR in the induction of myxomatous-mediating valvular myofibroblasts (MF) has been suggested. In an age-matched population of dogs with non-clinical and clinical MMVD, the objectives were to investigate (1) gene expression of 5-HT2AR and 5-HT2BR, (2) protein expression and spatial relationship of 5-HT2AR, 5-HT2BR and MF in the mitral valve (MV) and the cardiac anterior papillary muscle (AP) and (3) serum 5-HT concentrations. Gene expression of 5-HT2BR was significantly higher in MV and AP among dogs with clinical MMVD. This was not found for 5-HT2BR protein expression, though association of 5-HT2BR with myxomatous pathology and co-localization of 5-HT2BR and MF in MV and AP support a functional relationship, perhaps perpetuation of clinical MMVD. 5-HT2AR-expression and serum 5-HT showed no differences between groups.",
author = "Cremer, {Signe Emilie} and Moesgaard, {S. G.} and Rasmussen, {C. E.} and Zois, {N. E.} and T. Falk and Reimann, {Maria Josefine} and {Cirera Salicio}, Susanna and H. Aupperle and Oyama, {M. A.} and Olsen, {Lisbeth H{\o}ier}",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = mar,
day = "19",
doi = "10.1016/j.rvsc.2015.03.020",
language = "English",
volume = "100",
pages = "197--206",
journal = "Research in Veterinary Science",
issn = "0034-5288",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease

AU - Cremer, Signe Emilie

AU - Moesgaard, S. G.

AU - Rasmussen, C. E.

AU - Zois, N. E.

AU - Falk, T.

AU - Reimann, Maria Josefine

AU - Cirera Salicio, Susanna

AU - Aupperle, H.

AU - Oyama, M. A.

AU - Olsen, Lisbeth Høier

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/3/19

Y1 - 2015/3/19

N2 - Canine Myxomatous mitral valve disease (MMVD) is an age-related disease. Serotonin (5-HT) is implicated in the pathogenesis as locally-produced or platelet-derived. Involvement of the 5-HT2A receptor (R) and 5-HT2BR in the induction of myxomatous-mediating valvular myofibroblasts (MF) has been suggested. In an age-matched population of dogs with non-clinical and clinical MMVD, the objectives were to investigate (1) gene expression of 5-HT2AR and 5-HT2BR, (2) protein expression and spatial relationship of 5-HT2AR, 5-HT2BR and MF in the mitral valve (MV) and the cardiac anterior papillary muscle (AP) and (3) serum 5-HT concentrations. Gene expression of 5-HT2BR was significantly higher in MV and AP among dogs with clinical MMVD. This was not found for 5-HT2BR protein expression, though association of 5-HT2BR with myxomatous pathology and co-localization of 5-HT2BR and MF in MV and AP support a functional relationship, perhaps perpetuation of clinical MMVD. 5-HT2AR-expression and serum 5-HT showed no differences between groups.

AB - Canine Myxomatous mitral valve disease (MMVD) is an age-related disease. Serotonin (5-HT) is implicated in the pathogenesis as locally-produced or platelet-derived. Involvement of the 5-HT2A receptor (R) and 5-HT2BR in the induction of myxomatous-mediating valvular myofibroblasts (MF) has been suggested. In an age-matched population of dogs with non-clinical and clinical MMVD, the objectives were to investigate (1) gene expression of 5-HT2AR and 5-HT2BR, (2) protein expression and spatial relationship of 5-HT2AR, 5-HT2BR and MF in the mitral valve (MV) and the cardiac anterior papillary muscle (AP) and (3) serum 5-HT concentrations. Gene expression of 5-HT2BR was significantly higher in MV and AP among dogs with clinical MMVD. This was not found for 5-HT2BR protein expression, though association of 5-HT2BR with myxomatous pathology and co-localization of 5-HT2BR and MF in MV and AP support a functional relationship, perhaps perpetuation of clinical MMVD. 5-HT2AR-expression and serum 5-HT showed no differences between groups.

U2 - 10.1016/j.rvsc.2015.03.020

DO - 10.1016/j.rvsc.2015.03.020

M3 - Journal article

C2 - 25843893

VL - 100

SP - 197

EP - 206

JO - Research in Veterinary Science

JF - Research in Veterinary Science

SN - 0034-5288

ER -

ID: 137750892