A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. / Raffan, Eleanor; Dennis, Rowena J; O'Donovan, Conor J; Becker, Julia M; Scott, Robert A; Smith, Stephen P; Withers, David J; Wood, Claire J; Conci, Elena; Clements, Dylan N; Summers, Kim M; German, Alexander J; Mellersh, Cathryn S; Arendt, Maja L; Iyemere, Valentine P; Withers, Elaine; Söder, Josefin; Wernersson, Sara; Andersson, Göran; Lindblad-Toh, Kerstin; Yeo, Giles S H; O'Rahilly, Stephen.

I: Cell Metabolism, Bind 23, Nr. 5, 10.05.2016, s. 893-900.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Raffan, E, Dennis, RJ, O'Donovan, CJ, Becker, JM, Scott, RA, Smith, SP, Withers, DJ, Wood, CJ, Conci, E, Clements, DN, Summers, KM, German, AJ, Mellersh, CS, Arendt, ML, Iyemere, VP, Withers, E, Söder, J, Wernersson, S, Andersson, G, Lindblad-Toh, K, Yeo, GSH & O'Rahilly, S 2016, 'A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs', Cell Metabolism, bind 23, nr. 5, s. 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

APA

Raffan, E., Dennis, R. J., O'Donovan, C. J., Becker, J. M., Scott, R. A., Smith, S. P., Withers, D. J., Wood, C. J., Conci, E., Clements, D. N., Summers, K. M., German, A. J., Mellersh, C. S., Arendt, M. L., Iyemere, V. P., Withers, E., Söder, J., Wernersson, S., Andersson, G., ... O'Rahilly, S. (2016). A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metabolism, 23(5), 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

Vancouver

Raffan E, Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP o.a. A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metabolism. 2016 maj 10;23(5):893-900. https://doi.org/10.1016/j.cmet.2016.04.012

Author

Raffan, Eleanor ; Dennis, Rowena J ; O'Donovan, Conor J ; Becker, Julia M ; Scott, Robert A ; Smith, Stephen P ; Withers, David J ; Wood, Claire J ; Conci, Elena ; Clements, Dylan N ; Summers, Kim M ; German, Alexander J ; Mellersh, Cathryn S ; Arendt, Maja L ; Iyemere, Valentine P ; Withers, Elaine ; Söder, Josefin ; Wernersson, Sara ; Andersson, Göran ; Lindblad-Toh, Kerstin ; Yeo, Giles S H ; O'Rahilly, Stephen. / A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. I: Cell Metabolism. 2016 ; Bind 23, Nr. 5. s. 893-900.

Bibtex

@article{9c114decd4284580950c200292b91fed,
title = "A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs",
abstract = "Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.",
keywords = "Adiposity/genetics, Amino Acid Sequence, Animals, Appetite/genetics, Base Pairing, Base Sequence, Body Weight/genetics, COS Cells, Cercopithecus aethiops, Dogs, Feeding Behavior, Gene Deletion, Genotype, Obesity/genetics, Pro-Opiomelanocortin/chemistry, Receptors, Melanocortin/metabolism, beta-MSH/metabolism",
author = "Eleanor Raffan and Dennis, {Rowena J} and O'Donovan, {Conor J} and Becker, {Julia M} and Scott, {Robert A} and Smith, {Stephen P} and Withers, {David J} and Wood, {Claire J} and Elena Conci and Clements, {Dylan N} and Summers, {Kim M} and German, {Alexander J} and Mellersh, {Cathryn S} and Arendt, {Maja L} and Iyemere, {Valentine P} and Elaine Withers and Josefin S{\"o}der and Sara Wernersson and G{\"o}ran Andersson and Kerstin Lindblad-Toh and Yeo, {Giles S H} and Stephen O'Rahilly",
note = "Copyright {\textcopyright} 2016 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = may,
day = "10",
doi = "10.1016/j.cmet.2016.04.012",
language = "English",
volume = "23",
pages = "893--900",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

AU - Raffan, Eleanor

AU - Dennis, Rowena J

AU - O'Donovan, Conor J

AU - Becker, Julia M

AU - Scott, Robert A

AU - Smith, Stephen P

AU - Withers, David J

AU - Wood, Claire J

AU - Conci, Elena

AU - Clements, Dylan N

AU - Summers, Kim M

AU - German, Alexander J

AU - Mellersh, Cathryn S

AU - Arendt, Maja L

AU - Iyemere, Valentine P

AU - Withers, Elaine

AU - Söder, Josefin

AU - Wernersson, Sara

AU - Andersson, Göran

AU - Lindblad-Toh, Kerstin

AU - Yeo, Giles S H

AU - O'Rahilly, Stephen

N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016/5/10

Y1 - 2016/5/10

N2 - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

AB - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

KW - Adiposity/genetics

KW - Amino Acid Sequence

KW - Animals

KW - Appetite/genetics

KW - Base Pairing

KW - Base Sequence

KW - Body Weight/genetics

KW - COS Cells

KW - Cercopithecus aethiops

KW - Dogs

KW - Feeding Behavior

KW - Gene Deletion

KW - Genotype

KW - Obesity/genetics

KW - Pro-Opiomelanocortin/chemistry

KW - Receptors, Melanocortin/metabolism

KW - beta-MSH/metabolism

U2 - 10.1016/j.cmet.2016.04.012

DO - 10.1016/j.cmet.2016.04.012

M3 - Journal article

C2 - 27157046

VL - 23

SP - 893

EP - 900

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 5

ER -

ID: 209171994