Anne Marie Fog-Larsen, Master of Companion Animal Clinical Science
Anne Marie Fog-Larsen has attended the post-graduate program in Companion Animal Internal Medicine at the University of Copenhagen. She is a senior veterinarian in companion animal medicine at the Dept. of Veterinary Clinical Sciences, University of Copenhagen.
Read a brief of the Master’s thesis below:
Background: Alopecia X is an adult onset hair growth disorder seen primarily in double coated breeds such as Pomeranian, Alaskan Malamute, Samoyed, Keeshond and Siberian husky but has also been described in Miniature and Toy Poodles. The syndrome is poorly understood and it has never been proven whether Alopecia X can be considered a single distinct disease with the exact same etiology across breeds.
Objective: based on a systematic review of peer-reviewed scientific literature the aim of this study was to investigate whether Alopecia X can be considered a single distinct disease across breeds or whether the syndrome differs so much from breed to breed that it more appropriately should be considered different individual breed specific diseases.
Conclusions: Alopecia X is by far best elucidated in Pomeranians both in terms of clinical signs, histopathology, hormone analysis, response to different types of treatment and genetic analysis. The question of whether Alopecia X can be considered a distinct disease across breeds or more appropriately should be considered different breed specific diseases could not be answered due to the low number of dogs (other than Pomeranians) representing each breed and the heterogeneity, low evidence quality and poor methodological quality of the studies included in this systematic review. Well-designed and adequately powered studies with the purpose of accurately characterizing the disease at breed level are warranted.